2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2418):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-154042
    5’-Azido-5’-deoxy-2’-O,4’-C-methyleneuridine
    5’-Azido-5’-deoxy-2’-O,4’-C-methyleneuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 5’-Azido-5’-deoxy-2’-O,4’-C-methyleneuridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    5’-Azido-5’-deoxy-2’-O,4’-C-methyleneuridine
  • HY-154478
    3’-O-Acetyl-N2-iso-Butyroyl-2’-deoxy-guanosine
    3’-O-Acetyl-N2-iso-Butyroyl-2’-deoxy-guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-O-Acetyl-N2-iso-Butyroyl-2’-deoxy-guanosine
  • HY-154668
    5'-Homocytidine
    5'- Homocytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5'-Homocytidine
  • HY-180755
    cis-3-(3-Carboxyethenyl)-3,5-cyclohexadiene-1,2-diol
    cis-3-(3-Carboxyethenyl)-3,5-cyclohexadiene-1,2-diol (compound VII) is a metabolite of the dioxygenolytic pathway for initial catabolism of Hydrocinnamic acid (3-phenylpropionic acid) (HY-Y1088).
    cis-3-(3-Carboxyethenyl)-3,5-cyclohexadiene-1,2-diol
  • HY-154362
    1,2-Di-O-acetyl-3-deoxy-3-fluoro-5-O-(4-methyl)benzoyl-D-ribofuranose
    1,2-Di-O-acetyl-3-deoxy-3-fluoro-5-O-(4-methyl)benzoyl-D-ribofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    1,2-Di-O-acetyl-3-deoxy-3-fluoro-5-O-(4-methyl)benzoyl-D-ribofuranose
  • HY-180772
    Bis(glutathionyl)spermine
    Bis(glutathionyl)spermine is a glutathione-spermidine conjugate.
    Bis(glutathionyl)spermine
  • HY-W743885
    (3S)-2,3-Oxidosqualene
    (3S)-2,3-Oxidosqualene ((3S)-Squalene oxide; (S)-2,3-Epoxysqualene) is a nucleoside metabolite.
    (3S)-2,3-Oxidosqualene
  • HY-W770090
    CF 1743-d7
    CF 1743-d7 is the deuterium labeled Cf1743 (HY-107025). Cf1743 is a potent anti-varicella-zoster virus (VZV) bicyclic nucleoside analogue. Cf1743 has antiviral activity, with an IC50 of 3.3 μM for VZV thymidine kinase (TK).
    CF 1743-d<sub>7</sub>
  • HY-W394128
    2'-Deoxyinosine 5'-diphosphate
    2'-Deoxyinosine 5'-diphosphate (dIDP) is a nucleoside metabolite.
    2'-Deoxyinosine 5'-diphosphate
  • HY-152705
    5-Bromo-2’-deoxy-2’-fluoro-beta-D-arabinocytidine
    5-Bromo-2’-deoxy-2’-fluoro-beta-D-arabinocytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    5-Bromo-2’-deoxy-2’-fluoro-beta-D-arabinocytidine
  • HY-154842
    S-Gem
    S-Gem is a TrxR-dependent prodrug of Gemcitabine (HY-17026) and selectively activated by TrxR. S-Gem shows less cytotoxicity compared to Gemcitabine.
    S-Gem
  • HY-154370
    2’,3’-Bis-O-(t-butyldimethylsilyl)-N1-methylpseudouridine
    2’,3’-Bis-O-(t-butyldimethylsilyl)-N1-methylpseudouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’,3’-Bis-O-(t-butyldimethylsilyl)-N1-methylpseudouridine
  • HY-154547
    N2-iso-Butyroyl-3’-O-(methoxyethyl)guanosine
    N2-iso-Butyroyl-3’-O-(methoxyethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
    N2-iso-Butyroyl-3’-O-(methoxyethyl)guanosine
  • HY-152436
    7-Cyclopropylmethyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl) guanine
    7-Cyclopropylmethyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl) guanine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    7-Cyclopropylmethyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl) guanine
  • HY-152452
    2′-Amino-2′-deoxycytidine
    2′-Amino-2′-deoxycytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2′-Amino-2′-deoxycytidine
  • HY-128401
    Lysidine
    Lysidine (2-lysyl cytidine) is a lysine-containing Cytidine (HY-B0158) derivative. Lysidine can be found at the wobble position of bacterial AUA codon-specific tRNAIle. This modification determines both codon and amino acid specificities of tRNAIle.
    Lysidine
  • HY-154731
    9-(2’-O-Acetyl-5’-O-benzoyl-3’-O-methyl-beta-D-ribofuranosyl)-2,6-dichloropurine
    9-(2’-O-Acetyl-5’-O-benzoyl-3’-O-methyl-beta-D-ribofuranosyl)-2,6-dichloropurine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    9-(2’-O-Acetyl-5’-O-benzoyl-3’-O-methyl-beta-D-ribofuranosyl)-2,6-dichloropurine
  • HY-152419
    N6-(3-Methoxybenzyl)-2’-C-methyl adenosine
    N6-(3-Methoxybenzyl)-2’-C-methyl adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    N6-(3-Methoxybenzyl)-2’-C-methyl adenosine
  • HY-137619C
    Rp-dCTPαS tetrasodium
    Rp-dCTPαS tetrasodium is a sulfur-containing isomer of dGTP (HY-138616).
    Rp-dCTPαS tetrasodium
  • HY-W550365
    1-(alpha-L-Threofuranosyl)thymine
    1-(alpha-L-Threofuranosyl)thymine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    1-(alpha-L-Threofuranosyl)thymine